After just one win in their last five Premier League fixtures, Fulham are stuck in 18th place in the league with seven games left to play.
The last time Fulham gained a positive result in the Premier League was against champions Liverpool at Anfield in March.
With Fulham three points adrift of 17th placed Newcastle United just outside the bottom three, Andersen stressed the importance of their upcoming fixture against Wolves.
The Danish international believes that his Fulham side have the quality to pull of a massive win against Wolves when the two teams meet at Craven Cottage to keep their chances of staying up in the Premier League alive.
“A win would be massive”, Andersen told Fulham’s official site.
“At this time we need all the points we can get, and it’s a really good chance to get points I would say, so for me it’s a must-win game.
“I think we have a good chance to beat Wolves. It’s at home, and I feel we’re in a good spot to beat them.
“Like I’ve said many times, we feel good, we’re confident, and I’m sure we can have a great game against them.
“We still have full belief that we can stay in the Premier League.
“Nothing has changed.”
Fulham will look to make good on Andersen’s statements when they welcome Wolves to Craven Cottage on Friday.