Struijk was given his marching orders after his challenge left Liverpool’s Harvey Elliott with a dislocated ankle in Leeds’ 3-0 defeat to the Reds on Sunday.
The 22-year-old’s sending off was seen as harsh by many, including Elliott himself, who took to social media to express his support for the defender.
Feeling the challenge did not warrant a red card, Leeds approached the Football Association to overturn the dismissal on Tuesday.
However, it has emerged that the Football Association has rejected Struijk’s appeal against the suspension in what will be a huge blow to Leeds.
With the suspension standing, the Dutchman will now have to serve a three-match ban and will miss league games against Newcastle and West Ham.
Match referee Craig Pawson told the Football Association that the decision to show Struijk the red card was his, while VAR ruled that there was no clear or obvious error.
Leeds are already without Robin Koch and Diego Llorente, and Struijk’s suspension means that Liam Cooper is the only experienced centre-back available.